Overexpression of p53 and c-erbB-2 Oncogenes in Gastric Cancer
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Background: Gastric cancer still counts as one of the most common causes of cancer-related death in the world (Meyers, 1998). Aim: The aim of this study was to assess the presence of p53 and c-erbB-2 onceproteins in normal, dysplastic and malignant gastric tissues, with correlation to histopathological classification and lymph node metastasis. Materials and methods: Specimens from normal (n=18), dysplastic (n=14) and malignant gastric tissues (n=57) were collected from Pathology Departments of National Cancer Institute, Cairo University and Benha University Hospital. 36 cases of gastric cancer showed lymph node metastasis. Histopathological classification was performed on hematoxylin and eosin stained sections, Immunohistochernical expression of p53 and c-erbB-2 was estimated using avidin-biotin-peroxidase complex method. Results: None of normal, or dysplastic gastric mucosa showed nuclear p53 immunoreactivity, while p53 expression was observed in 54% of gastric cancer (36% differentiated adenocarcinoma and 69% undifferentiated type). Expression of c-erbB-2 was observed in 7% only of dysplastic mucosa and in 68% of gastric carcinoma (76% differentiated and 62.5% undifferentiated variety). Expression of p53, was significantly high in gastric carcinomas with lymph node metastasis than in cancers with negative lymph node metastasis p value < 0.01. Conclusion: This study provide further evidence that expression of both p53 and c-erbB-2 had a role in gastric carcinogenesis and constitute additional criteria of high grade of malignancy. At the same time the p53 expression is an important prognostic indicator for patients with gastric carcinoma than c-erbB-2.