EVALUATION OF FHIT PROTEIN AND P27 IN NON SMALL CELL LUNG CANCER (NSCLC) : AN IMMUNOHISTOCHEMICAL STUDY
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Aim: The present study aims at assessment of the role of Fragile Histidin Triad (FHIT) tumor suppressor gene and p27 gene in the pathogenesis of Non Small Cell Lung Cancer (NSCLC) as well as their role in the behavior of the examined cases. Methods and Results: Fifty cases of NSCLC and 8 apparently normal lung tissues were investigated immunohistochemically for the detection of FHIT and p27 protein expression. The results showed that loss of FHIT protein expression was found in 68% of the NSCLC cases. This was significantly correlated with pathologic stage of the examined tumors (p<0.05). Also FHIT expression was significantly reduced in NSCLC from smokeis than it was in tumors from nonsmokers (p < 0.05). p27 was negative and reduced in 84% of the NSCLC cases. The results showed also an inversely proportionate correlation between p27 expression and NSCLC grade which was statistically significant (P<0.05). Comparing the irnmurtostaining results of both p27 and FHIT in NSCLCs showing that there was a highly significant positive correlation between their expression in these neoplasms (p <0.01). Conclusion: Both p27 alteration and reduced FHIT protein expression might have an important role in the pathogenesis of NSCLC. Whether p27 alteration downregul ate FHIT protein expression or alteration of both p27 and FHIT protein expression are coincidental independent tumorigenic events, remains to be fully understood. In cases of NSCLC, FHIT gene might be the target of csircinogenesis in cigarette smoke. In spite of the significant correlation between reduced FHIT and p27 169 Abd El-Lath f M. El-Balshy et al... protein expression compared with tumor stage and grade respectively, their prognostic value in NSCLC remains to be established.