HUMAN PLACENTA ASSOCIATED WITH PRE-ECLAMPSIA AND DIABETES MELLITUS "HISTOPATHOLOGICAL AND MORPHOMETRIC STUDY
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Biopsy specimens of different quarters of placentae from 20 uncomplicated pregnancies (control) and forty cases of complicated pregnancies with pre-eclampsia and diabetes mellitus, were routinely processed stained by Haematoxylin and Eosin, Masson-Trichrome and P.A.S. stains to evaluate the histopathological (villous and vascular) changes. The most common villous lesions found in pre-eclampsia were infarction, cytotrophoblastic hyperplasia and there were significant increase in number of villi and syncytial knots. While in diabetic cases there was villous congestion and edema, villous fibrosis and fibrinoid necrosis and there was also significant increase in number of villi and syncytial knots. Morphometric study of trophoblastic basement membrane; villous capillary basement membrane and foetal blood vessel wall revealed significant increase in thickness in both pre-eclamptic and diabetic cases, yet it was higher in diabetic cases.