A comparative Histological and Histochemical studies on the effects of Diclofenac and Meloxicam on the mucosa of the stomach and duodenum of a male adult albino rats.
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Non streoidal antiinflammatory drugs (NSAIDs) known to have adverse drug reaction specially on the gastro-intestinal tract. The present work studied the histological and some histochemical effects of the therapeutic dose (for 2 different periods of time) of both Diclofenac sodium (voltaren) which is widly used NSAID and Meloxicam (mobic) which is a new NSAID on the stomach and duodenum. In the rats which treated with voltaran, the histological results revealed mononuclear cellular infilitration in the connective tissue corium, dilated engorged blood vessels in the deep part of fundic mucosa which might be a preceding stage to ulceration and bleeding of stomach and hypertrophy of some parts and dilatation of the lumina of secretory region of the glands in both stomach and duodenum. These changes became more evident by increasing duration of voltaren imake.On the other hand no obvious changes can be seen in the groups of animals that have received the mobic and the picture is more or less similar to the control. The histochemical results revealed a decrease in the PAS reaction specially in the group which have received voltarene for a long time. - I. As regards the nucleic acid content, the only change was the decrease of RNA content, this decrease of reaction showed a patchy pattern along the mucosa.