URIC ACID CURVE : AN EVIDENCE OF INFLUENCE OF SERUM OESTROGEN LEVEL) ON SERUM URIC ACID
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During the fertile age women showed a lower serum w-ate than men of similar ages. The intersexual difference is thought to be related to a higher renal clearance of urate possibly due to their higher plasma oestrogen level. We correlated between the cyclic changes of S. oestrogen and S. Uric acid during the menstrual cycle. S. oestrogen and S. uric acid were estimated at days 1. 7, 14. 21 and 28 of menstrual cycle in 20 normal age-fertile non married women. The progressive rise of S. oestrogen in the 1st half of the menstrual cycle was accompanied by a progressive decrease of S. uric acid and its progressive decrease in the 2nd half was accompanied by a progressive increase in S. uric acid. S. uric acid changes were plotted as a curve which is nearly a mirror of the S. oestrogen curve and so it could be used to give an idea about the physiologic oestrogen curve in females. The correlation test betwgen the two curves indicated that the suggested influence of S. oestrogen on S. uric acid is neither direct nor absolute, perhaps through a physiological mechanism including more than one factor in add Won to S. oestrogen.