STUDY OF THE HAEMODYNAMICS AND RESPIRATORY CHANGES DURING TOTAL INTRAVENOUS ANAESTHETIC USING FENTANYL AND KETAMENE
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Intravenous fentanyl and ketamine in combination with pancuroniwn and oxygen for anaesthesia were used in 40 adult male pateints (ASA I and II) undergoing hemiorrhaphy surgery. All patients were premedicated with midazolam 8 mg and atropine 0.6 mg. Patients were divided into 2 groups according to drug used. The mean fentanyl infusion rate required for stable anaesthesia was 4.8 1.2 ug /minute and the mean ketamine infusion rate was 3.4 mg / minute. The fentanyl group showed cardiovas cular stability (heart rate, systolic, diastolic, mean arterial pressure and B. C. G.) during induction, skin incision and at the end of infusion com pared with ketamine group which showed significant (P < 0.05 - P < 0.01) increase in the above cardiovascular parameters. Arteiial oxygen satura tion Pso2 and ETco2for both groups showed insignificant changes from the basal line. The recovery was smooth and the mean recovery time was (4 1 minutes) after fentanyl and (16 4) minutes after ketamine infusion with no post operative complain from awamess.