A STUDY OF SIALIC ACID IN MYOCARDIAL INFARCTION
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Serum total sialic acid, serum cholesterol and plasma fibrinogen were assayed in fifteen patients (10 males and 5 females) who had a myocardial infarction. Their ages ranged 45- 58, with a mean age of 52 ± 3.5 years. Another fifteen normal individuals (9 males and 6 females) were used as a control group. Their ages ranged 41 - 57 , with a mean value of 47 ± 4.5 years. The mean serum sialic acid in acute myocardial infarction group was significantly higher (P <0.001) when compared with the control group. There was no sex difference with respect to serum sialic acid and , also its level did not correlate with the age of subjects. A significant positive correlation between serum sialic acid and plasma fibrinogen (r — 0.624, P <0.01) and also with serum cholesterol (r 0.499, P < 0.05) in acute myocardial infarction group was found. Also there was a significant positive correlation between serum sialic acid and plasma fibrinogen in control group ( r = 0.98, P < 0.001). It was therefore , concluded that the measurement of sialic acid in serum seemed to provide a rapid and simple index as acute phase reactant in myocardial infarction patients.