EVALUATION OF THE VALUE OF INTRAPERITONEAL MEPERIDINE AFTER LAPAROSCOPIC CHOLECYSTECTOMY
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Patients undergoing laparoscopic procedures may experience postoperative pain. Opioids can produce peripheral analgesic effects by activation of opioid receptors on sensory nerves. This study was designed to examine a novel route of administration of meperidine, the intraperitoneal injection (IP). At the end of laparoscopic cholecystectomy 100 patients received 80 ml of 0.125% bupivacaine with 1:200,000 epinephrine IP and 50 mg of meperidine either IP or IM. Postoperative pain scores were measured at rest and with movement. Pain scores were significantly lower in the group receiving the IP meperidine both at rest (p<0.01) and with movement (p<0.05). We conclude that the combination of intraperitoneal bupivacaine and intraperitoneal meperidine was better than the combination of IP bupivacaine and IM meperidine for postoperative analgesia in patients undergoing laparoscopic cholecystectomy.