Injection pain with propofol is experienced more frequently by the unpremedicated patient, and when the drug is introduced via small veins. Various strategies have been advocated to reduce injection pain. The airn of this study is to evaluate the effect of using combined methods to alleviate this pain. This study included 200 patients of both sexes, ASA grade I or 11. aged 15-50 years, presenting for surgery under general anaesthesia, were randomly distributed into 4 groups (n = 50 for each group). Patients received either 2m1 0.9% saline (group 1), 20 mg lignocaine (group 2)fentanyl 100pg (group 3) or ketamirte lOrng (group 4) 30 second 'before administration of 19ml propofol 1% immediately mixed with 20rrzg lignocaine. The incidence of pain was 32%, 26%. 8% and 12% in groups I. 2, 3 and 4 respectively. Also no cases of severe pain in groups 3 and 4 while group (1) have 6 patient and group (2) have 5 patients. As regard pain recalled. 3 hours after the end of operation, there were significant increase in number of patient with no pain in group 2, 3 and 4 compared to group 1. Also patients with no recall significantly increase in group (3) compared to other groups. Mixture of lignocaine 20rng with propofol when used after pretreatment using either fentanyl 100pg or ketamirte 10 mg are more effective in reducing both the incidence and severity of injection pain into a vein on the dorsum of the hand. When same mixture of lignocaine 20mg with propofol was used after pretreatment using 20 mg lignocaine no signyicant difference is present. |
