ENDOCRINAL AND METABOLIC IMPACT OF GENERAL ANESTHESIA IN NON-INSULIN DEPENDENT DIABETICS UNDERGOING CATARACT SURGERY
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The stress response is a part of the systemic reaction to injury, which encompasses a wide range of endocrinological, metabolic, immunological and hematological effects. The stress response to surgery may be modified by anesthetic intervention. This study was designed to determine the effects imposed by the type of anesthesia, used during cataract surgery, on patients' stress response to surgery. Methods: This prospective study comprised 40 patients assigned to undergo cataract surgery. There were 20 non-diabetic patients (group I), and 20 controlled non-insulin diabetes mellitus (NIDDM) patients (group II), 20 patients were anesthetized using peribulbar local infiltration anesthesia (LA) (group la & Ha), and the other 20 patients received general anesthesia (GA) (group Ib & lib). Three venous blood samples, preoperative, intraoperative (IO) and 2 hours postoperatively (P.O.), were taken and divided into two parts. The first part was put in tube containing sodium fluoride and anticoagulant for estimation of blood glucose (BG), pyruvate, and lactate. The second part was left to clot, centrifuged, and supernatant was separated for estimation of serum urea, creatinine, cortisol, and Cpeptide levels.