A POSSIBLE EXPLANATION FOR DECREASED CATECHOLAMINES SECRETION IN CHRONIC DIABETIC RATS
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The present study was designed to demonstrate a possibl explanation for decreased catecholamines secretion in chronic diabetic rats. Thirty male albino rats were included in this study. The rats were received at -120 days of age and twenty rats were made diabetic by intraperitoneal injections of alloxan 150 my / kg . Diabetic rats were received daily iryec- Lions of protamine zinc insulin arid were maintained in mildly hyperglycaemic state (200- 250 mg / dl). The remaining 10 rats were used as matched controls and were injected with the solvent. Sbc diabetic rats were excluded from this study (2 rats were died after alloxan injection and other 4 diabetic rats due to uncontrolled their blood glucose levels). Epinephrine and norepinephrine were estimated in right adrenal gland and also in 5 minute perfus ate fractions from left adrenal gland by using the retrograde perfusion technique of Wakade (1981), after 4 months of appearance of IDDM in diabetic rats There was non signcant difference between diabetic rats and matched controls with respect to epinephrine and norepinephrine contents of right adrenal gland. There was a significant redaction in secretions of epinephrine and norepinephrine in 5-minute perfus ate fractions of left adrenal gland in diabetic rats compared with matched controls. In conclusion, decreased secretion of catecholamines from adrenal medulla in a chronic diabetes is not due to decreased synthesis or storage abnormalities but may be due to chromatin cell defect and or degeneration within the presynaptic endings of the greater splanchnic nerves.