THE APPLICABILITY OF BIOMARKERS FOR DIFFERENTIATION OF INVERTED PAPILLOMA WITH DIFFERENT PATHOLOGICAL DIAGNOSES
|Full paper||Not Available|
Objectives: The present study aimed tolestimation of tissue extract epidermal growth factor receptor (EGFR) and serum squamou_s cell carcinoma. antigen (SCCA) levels in patients with inverted papilloma (IP) in varied pathological states as a trial to determine their role in pathogenesis and/ or their applicability for differentiation between these different patho/ogical changes. • Patients & Methods: The study included 6 cases with primarily diagnosed IF. 4 cases with recurrent IF and 3 cases had IF with SCC and 10 healthy volunteers to give blood samples as control group. All patients underwent full history taking. general and local examination and CT irnag- • ing was conducted. All cases underwent endoscopical excision and freshly excised IF tissues were divided into two parts: the first for histopathological examination and the second was immediately frozen on dry ice and stored in liquid nitrogen at -70°C until processed for estimationof tissue extract level of EGFR. Venous blood samples were obtained prior to and after surgical resection for ELISA estimation of serum SCCA. Results: The study included 13 patients: 10 males and 3 females. with mean age of 62.4+6.2 years. Nasal obstruction was the main presenting symptom followed by epistcods arid headache. Patients with recurrent IF gave history of previous endoscopic removal since a mean duration of . 6.24-2.2 months and one patient had recurrent IF twice. Histopathological examination documented the diagnosis of benign IP in 10 cases and SCC changes in 3 IP. Mean EGFR levels estimated in tissue extract of IP with SCC was signOcantly higher compared to benign IF with significantly higher levels in recurrent IF compared to primary IP.