SERUM LEVEL AND DIURNAL ninicrtim Of CORT1SOL AND MELATONIN IN PATIENTS WITH FIBRONIYALGIA SYNDROME,
|Full paper||Not Available|
Fibromyalgia (FM) is a common syndrome of musculo — skeletal pain and fatigue .Sleep disturbances have been suggested to play a central role in the pathophysiology of FM .This study included 30 female patients with fibromyalgia syndrome (FMS)with mean age of 33±7.6 years and mean disease duration of 5.4±1.8 years. Fifteen age and sex matched normal controls were also included in the study.We estimated the level of serum cortisol and melatonin at 8 a.m. and 10 p.m. in both groups. Serum cortisol and melatonin were significantly lower in FMS patients than in the control group at 8 a. m. and 10 p.m. Also there was non significant difference between the 8 a.m. and the 10 p.m. serum levels of cortisol and of melatonin i.e. loss of diurnal rhythm of cortisol and melatonin in FMS patients.The cortisol finding may be due to a relative adrenal hyporesponsiveness, while the melatonin finding may be due to a decrease in N-acetyltransferase activity in FMS . We concluded that the changes of serum cortisol and melatonin levels might explain the fatigue, widespread pain and tenderness and the dysregulation of the sleep that occur in patients with FMS.