Publications of Faculty of Medicine:AUDITORY INVOLVEMENT IN HYPERURICEMIA: Abstract

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Hyperuricemia is suggested as risk of sensorineural hearing loss. This study aimed to evaluate cochlear function in group of patients with hyperuricemia. We studied the auditory function in 25 patients with primary hyperuricemia using pure-tone audiometry and transient evoked otoacoustic emission (TEOAEs) analysis. We hypothesized that vascular compromise, is in part, could be responsible; hence carotid dopplex ultrasongraphy was done to assess the common carotid artery intima-media thickness (CCA-IMT), an early marker for atherosclerosis and transcranfal doppler ultrasonography (TCD) was also done to the basal intracranial vessels. Compared to control subjects, the mean hearing threshold and pure tone audiometer), were within normal agedependent ranges. Patients reported significant reduction in the amplitude of TEOAEs at 4 kHz (P<0.01). Significant correlation was identified between TEOAE and uric acid level, patients' age, duration of illness, CCA-IMT, MFVs of the middle cerebral arteries and vertebral arteries. These data imply that TEOAEs is a useful method for detection of subclinical cochlear compromise in patients with hyperuricemia. It is possible that hyperuricemia could be accompanied by increased stiffness and/or compromise the blood supply of the outer hair cells, which will impair their electromotile response. The human data should be supplemented with animal data.