THE EFFECTS OF ENDOGENOUS ESTROGEN RECEPTOR BLOCKER ON TESTICULAR FUNCTION IN RATS
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The effects of estrogen receptor blockage by tarnorcifen on testicular function and reproduction were evaluated in mole albino rats. Tamoxifen treatment in two doses ( 100 and 400 ug / d ) and for different periods ( 10,20.60 and 90 days) resulted in an initial increase in serum FSH levels ( after 10 and 20 days of treatment), which returns back to the control level after 60 and 90 days. Serum LH, serum testosterone and testicular testosterone levels are all decreased by tarnoxifen treatment . The decreased serum LH suggests that tcunoxifen may act as estrogen agonist at the hypothalamo-pituitary axis, inhibiting pituitary LH secretion. Tamoxifen decreased both serum and testicular testosterone levels and altered testicular weight and spermatogenesis, resulting in decreased sperm count and increased sperm abnormalities and acrosomal damage. It could be concluded that, endogenous mole estrogen is an important male hormone and estrogen receptor blockage by tamoxifen decreased male fertility .