ROLE OF INTERLEUKIN 6 IN PROGNOSIS OF ORAL SQUAMOUS CELL CARCINOMA
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Background: Since morbidity and mortality rates due to oral cavity and oropharyngeal squamous cell carcinoma (OSCC) have improved little in the past 30 years, early detection or prevention of this disease is likely to be most effective. Interleukin (IL) 6 is one of these cytokines may contribute to the pathogenesis of this disease, and have been linked with increased tumor growth and metastasis. Objectives: To investigate the role of interleukin 6 in prognosis of oral squamous cell carcinoma. Patients and Methods: the study included 20 patients with oral squamous cell carcinoma (OSCC) T1 and T2, they were subjected to surgery, serum interleukin 6 were estimated before one week before surgery and 6 month after surgery by using Enzyme-linked immunosorbent assay (ELISA) technique. 10 normal subjects were used as control group. Results: there were significant difference of interleukin 6 serum level one week before and after 6 month of surgery (p<05) and significant difference between one week before surgery and control group while insignificant difference between control group and 6 month after surgery. Conclusion: our findings showed that serum interleukin 6 present in high levels in oral squamous cell carcinoma and decreased after eradication of the disease so it hold promises as biomarker for oral squamous cell carcinoma and it is effective adjunctive tool in the follow-up patients with OSCC.