Publications of Faculty of Medicine:Nasal Septal Perforation: Acellular Human Dermal Allograft, A New Material For Reconstruction: Abstract

Nasal Septal Perforation: Acellular Human Dermal Allograft, A New Material For Reconstruction
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This study was designed to evaluate the use of acellular human dermal graft (A IloDerrn, Life- Cell Corporation, The Woodlands, Texas) in the repair of septa! perforation through the external open approach. The included 10 adult male patients with a mean age of 28.715.1 years with nasal septal perforation size ranging from 10 to 30 mm. In 7 patients total closure of the mucoperichondrial flaps was achieved during the operation, while in the other 3 patients total closure of the mucoperichondried flaps on both sides was not achieved No cases of infection or rejection of the allograft were recorded. Through the follow-up period, the 7 patients in whom closure of the mucoperichontal flaps was achieved none of them had either residual or recurrent perforation. In the other 3 patients, there was residual perforation. However, the mean size of the initial perforation in these three patients (25±5; range 20-30 mm) was reduced to 6.7±2.9; range 5-10 mm. It can be concluded that AlloDerrn dermal graft can be used successfully for managing cases with nasal septal perforation of any size through an external rhinoplasty approach. This mode of construction reduced the operative time and gave high success rate without donor site morbidity, operative site infection or graft rejection.