RECURRENT ACUTE OTITIS MEDIA IN CHILDREN : IMMUNOGLOBULIN STUDY
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Total IgG, 19A, IgM, IgG subclasses IgG 1. IgG2, Ig03. IgG4 and antipneumococcal antibody titers were measured in 25 patients with recurrent acute otitis media (r-A.O.M). There was no significant difiference between patient population and control group as regard to the total IgM, IgA. IgG and 19G subclasses Ig G3 ez. Ig04 whereas IgG 1, IgG2 shows a significant difference. Low 1901 and IgG2 has been associated with impaired immune responsiveness to polysacchride antigens. Children who had normal immunoglobulin 10G. IgA, 1gM and subclass levels but had a defect in the production of antibodies specific for pnew mococcal capsular antigens had been identified. We recommended (1) Further studies to involve a big number of cases to evaluate the immune aspects of recurrent acute otitis media especialy the selective deficiency of specific pneumococcal antibodies .(2) trials of polyvalent artticapsular polysaccharide vaccines for patients older than 2 years with low peneumococcal antibody titers and (3) passsive immuneprophylaxis can be applied to children under 2 years old suffering from IgG 1, IgG2 with low or no specific antipneumococcal (or anti. H. influenzae) antibodies.