The influence of leptin in obese female rats and obese women on female reproductive function and fertility
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This study was carried out to investigate the influence of leptin in obese female rats and obese women on female reproductive function and fertility. Our study included four groups; group I (female rats received low fat diet), group II (female rats received high fat diet), group III (lean infertile females) and group IV (obese infertile females). Sera of female rats and women were assayed for detection levels of leptin, FSH, LH, estradiol (E2) and testosterone. Results of this study showed that obese female rats and obese infertile women had significantly higher levels of leptin, LH, E2 & testosterone and significantly lower levels i of FSH compared with female rats received low fat diet and lean infertile women. In obese females the increased leptin levels may be increasing peripheral aromatization of androgen to estrogen, also increased leptin levels can be increasing testosterone levels by decreasing SHBG. As regards the effect of increased leptin levels on decreasing FSH levels, may be occurring by direct negative central effect. The increased LH levels in obese females may be attributed to direct positive central effect of increased leptin. Increased LH/FSH ratio unfavorable for folliculogensis, leading to infertility.