Oxygen radical activation had been suggested to be involved in the pathogenesis of hepatocellular damage. They are produced in conditions characterized by oxidative stress and determine peroxidation of polyunsaturated fatty acids. Determination of lipid peroxide products had frequently been used as a measure of oxygen radical activation. Also, sialic acid (total & lipid-bound) may be disturbed in inflammation and malignancy. So, the aim of this work is to study the relationship between lipid peroxides (LP) and lipid-bound sialic acid (LSA), total sialic acid (TSA), a-fetoprotein (AFP) in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) and to evaluate LSA & TSA as tumor markers in HCC. The present study included two groups of patients. The first group included 20 patients with LC, their age ranged from (40-60) years. The second group included 20 patients with HCC, their age ranged from (38-67 years). These groups of patients were compared with 10 healthy individuals (control group), the age and sex were matched with patient groups. The study showed that, in patients with LC and HCC, there was a significant (P<0.001) increase of lipid peroxides (LP), lipid-bound sialic acid (LSA), and total sialic acid (TSA) than the control group. While serum AFP was significantly (P<0.001) increased in patients with HCC than the control group Also, there was a significant positive correlation between serum LP and LSA (P<0.01, r=0.561, & P<0.001, r=0.693, respectively), TSA (P<0.001, r=0.678 & PO.001, r=0.867, respectively) in patients with LC and HCC. Moreover, there was a significant positive correlation between serum LP and AFP with HCC. Serum LSA was a more sensitive biochemical marker (85%) than TSA (70%) and serum AFP (55%),
Bull. Egypt. Soc. Physiol. Sci., 20 (1) 2000
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