Background: Despite the several studies suggesting the genetic basis of acne vulgaris,
the exact genetic architecture of this very common condition is not yet clear.
Aim of the work: This study aimed to investigate the association between IL-1A
(889) gene polymorphism and acne vulgaris in a sample of patients.
Subjects and Method: Blood samples from 100 patients with acne vulgaris and 100
healthy age, sex, and BMI matched controls were obtained. DNA samples were isolated
from blood cells, and the PCR-RFLP method was used for genotyping.
Results: The genotype distributions of IL-1A (889) polymorphism were as
expected under Hardy-Weinberg equilibrium. T allele was predominant in the
patients, while C allele predominated in the control subjects (P value < .001). The
frequency of TT genotype in patients was significantly higher than in the control
subjects (P value < .001). CT genotype was significantly more frequent in the control
subjects compared to patients (P value < .001). Among the 47 patients who
reported diet as a risk factor for triggering or exacerbating their lesions, 62.5% had
TT genotype (P value = .038).
Conclusion: IL-1A (889) gene polymorphism has a role in the pathogenesis of
acne vulgaris. We suggest that the triggering or exacerbating effect of diet on acne
may be related to IL-1A (889) gene polymorphism