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Dr. Abdelmotaal Abdelmajeid El-Shiekh Abdelmotaal Abdelmajeid :: Publications:

Synthesis of quinazoline derivatives as potential antimicrobial agents
Authors: Mohamed S. Behalo · Abdelmotaal Abdelmajeid · Aly A. Aly · Kaouser A. Hebash · Enas A. Mohamed ·
Year: 2015
Keywords: Benzoxazinone, quinazolinone, amino acids, antimicrobial activity.
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: 1st international conference of faculty of science, Benha university, Role of applied science development and society services 5-6 sept. 2015, cairo. Egypt.
Local/International: Local
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available

An efficient synthesis of substituted quinazoline derivatives was achieved from the reaction of 2-((1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)methyl)-4H-benzo[d][1,3] oxazin-4-one (3) as a reactive starting material with variety of nucleophilic reagents. The Structural formula of all derivatives were confirmed and characterized by elemental analysis and spectral data. Some of the synthesized compounds were also screened for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds showed potent to weak antimicrobial activities.

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