The use of the fiberoptic bronchoscope to perform BAL and the analysis of cells and proteins in the recovered fluid has received wide spread attention as an investigative tool since its introduction.
This study aimed at studying the biochemical changes of broncho-alveolar lavage in smokers as compared to non smokers and finding the difference between cigarette and goza smokers.
To achieve this aim, 49 males were studied. !They were classified into four groups: -Group I: Symptomless cigarette smokers: Including 21 subjects who
were further subdivided into 3 subgroups according to
smoking index by Nitti (1976):
Group I-a: 14 mild cigarette smokers.
Group I-b: 6 moderate cigarette smokers.
Group I-c: 1 heavy cigarette smoker.
-Group II: Symptomless goza smokers: Including 8 subjects who
were subdivided into:
Group II-a: 7 mild goza smokers.
Group II-b: 1 moderate goza smoker.
-Group III: Symptomless mixed cigarette and goza smokers including 8 subjects who were subdivided into: Group III-a: 4 mild mixed smokers. Group III-b: 2 moderate mixed smokers. Group In-c: 2 heavy mixed smokers.
-Group IV: Control healthy non smokers including 12 subjects.
For all subjects careful history taking and clinical examination, hepatic and renal function profile, chest X-ray, pulmonary function tests and fiberoptic bronchoscopy were done. Estimation of
i mm unogl 0 bulins A and G, carci no embryo nic antigen and
al-antitrypsin concentrations were done both in serum and
bronchoalveolar lavage fluid.
Data were tabulated, coded and entered into a computer then analysed using SPSSIPC +
Results were expressed as mean ± standard deviation. The student's t-test, paired t-test, correlation coefficient and ANOV A tests were used for analysis.
Results obtained !Were:
-Smokers specially goza and mixed smokers had significantly lower forced vital capacity (FVC) than that of nonsmokers.
-Both cigarette and goza smokers had significantly lower forced expiratory volume in 1 second (FEVl) than