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Prof. Ahmed Mostafa Sadek Rafaa :: Publications: |
|
| Title: | Revisiting the management of
recurrent implantation failure
through freeze-all policy |
| Authors: | Yasmin Magdi, M.Sc.,a Ahmed El-Damen, M.Sc.,b Ahmed Mohamed Fathi, M.Sc.,cAhmed Mostafa Abdelaziz, M.D.,d Mohamed Abd-Elfatah Youssef, M.D., Ph.D.,eAhmed Abd-Elmaged Abd-Allah, M.D.,e Mona Ahmed Elawady, M.D.,f Mohamed Ahmed Ibrahim, M.D.,dand Yehia |
| Year: | 2017 |
| Keywords: | Freeze all policy, recurrent implantation failure |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Ahmed Mostafa Sadek Rafaa_paper 1.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Objective: To determine whether a freeze-all policy for in vitro human blastocysts improves the ongoing pregnancy rate in patients with recurrent implantation failure (RIF). Design: Prospective cohort study. Setting: Single private center. Patient(s): A total of 171 women with RIF divided into two groups: freeze-all policy group (n ¼ 81) and fresh embryo transfer (ET) group (n ¼ 90). Intervention(s): Freeze-all policy. Main Outcome Measure(s): Ongoing pregnancy rate. Result(s): The clinical pregnancy rate (52% vs. 28%; odds ratio [OR] 1.86; 95% confidence interval [CI], 1.29–2.68) and ongoing pregnancy rate (44% vs. 20%; OR 2.2; 95% CI, 1.04–3.45) were statistically significantly higher in the freeze-all group than the fresh ET group, respectively. The implantation rate was also statistically significant (freeze-all group 44.2% vs. fresh ET group 15.8%; OR 2.80; 95% CI, 2.00–3.92). Conclusion(s): The freeze-all policy statistically significantly improved the ongoing pregnancy and implantation rates. Thus, a freezeall policy is likely to be the new key to helping open the black box of RIF. These findings also are useful for further investigating the adverse effect of controlled ovarian stimulation on in vitro fertilization outcomes. (Fertil Steril 2017;-:-–-. 2017 by American Society for Reproductive Medicine.) |
