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Prof. Amal Ahmed :: Publications:

Title:
Study of Labeling and Stability of 188Re-NTMP Complex
Authors: M.T.El-Kolaly, M. A. Motaleb and M. Y. Nassar٭
Year: 2013
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available
Abstract:

Labeling of nitrilotris(methylene phosphonic)acid (NTMP) with rhenium-188 using stannous chloride as a reducing agent was investigated. Dependence of the yield of the 188Re-NTMP complex on the concentration of the reducing agent, pH, reaction time, temperature, ascorbic acid and amount of carrier added was studied. Under optimum conditions, the labeling yield of 188Re-NTMP complex was 90% for the carrier-free 188Re but with the carrier-added 188Re the labeling yield was more than 97%. Furthermore, the stability of the 188Re-NTMP complex against pH change and dilution with saline was also studied. It was found that the addition of carrier stabilized the 188Re-NTMP complex against pH change and dilution.

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