: Blended learning increases the options for greater quality and quantity of human interaction in a learning environment. Blended learning offers learners the opportunity "to be both together and apart". A community of learners can interact at anytime and anywhere because of the benefits. Aim of the study: was to evaluate the effectiveness of simulation versus blended learning regarding to vein puncture procedure on second year nursing students 'performance at Faculty of Nursing, Benha University. A quasi-experimental research design was utilized to conduct the aim of this study Subject: A purposive sample 2nd year nursing students (320 students) in academic years (2017&2018) were recruited in this study and divided into control and study groups (160 students in each group) the control group were used SimMan and a study group were used Blended learning. The study tools used for data collection of this study; First tool: Nursing students' self-administered questionnaire. Second tool: Nursing students' practice observational checklist for vein puncture. Third tool: program satisfactory nursing student's opinionire .The results : there were highly statistically significant differences between mean score of students' knowledge & practice regarding vein puncture in both control and study groups (P0.05) . Conclusion :The two used learning methods ( simulation & blended learning) had positive effect on 2nd year nursing students 'knowledge and practice but blended learning method had highly statistically significant effect on students' performance versus simulation. The study recommended Additional researches are needed to be conducted on the use of blended learning in the nursing educational institution as a teaching- learning method to overcome the problems related to in availability of using simulators.
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