Atrial septal defect (ASD) is the most common congenital heart disease (CHD) in adults after
bicuspid aortic valve. Although the defect is often asymptomatic until adulthood, undetected ASDs could lead to
potential irreversible complications like arrhythmias, stroke, pulmonary hypertension and its squeal.
The purpose of our study was to determine the value of surgical closure of atrial septal defects in adults and the
effect of age on the prognosis of these patients.
Methods and patients: Retrospective study was carried out on 489 patients with age 18 to 65 years old who
underwent surgical repair of isolated Secundum type ASD. There were 318 women and 171 men (mean age
was25.21 ± 10.106 years). The patients were divided into two groups, group I: from 18-40 years old. Group II: 40-65
years old. Preoperative, operative, and postoperative data were reviewed. Statistical analysis was performed.
Results: A statistically significant improvement of NYHA Functional class, tricuspid valve regurgitation and
pulmonary artery pressure in most of the patients after operation. No residual intra-cardiac shunt was identified on
echocardiographic follow up. Postoperative morbidity and mortality were higher in the older patients with high
Conclusion: Surgery for ASD in the adult age is a safe, beneficial, and a low-risk option that modifies the
patient’s natural history by improving their clinical status. The operation must be performed without major delay,
better to be in established GUCH centers by well trained staff. Despite the use of sildenafil is still need more
research. It seems to have good result post-operative.