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Prof. Evat Isaac :: Publications:
Novel synthesis of phthalazine derivatives as antimicrobial agents
|Authors:||Yvette Issac, Eman El-Karim, Shafie Donia, Mohamed Behalow|
|Paper Link:||Not Available|
|Full paper||Not Available|
|Supplementary materials||Not Available|
Reaction of 4-(phenoxathiin-2-yl)-1-oxy or mercaptophthalazines 2a, c with phthalyl or tosylamino acids 3 and 4 has been found to yield 5, 6a-j. Hydrazinolysis of 5, 6a-e furnished amino derivatives 5, 6k-o. Some of the newly synthesized products were tested for their antimicrobial activities.