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Prof. Evat Isaac :: Publications:
Model Studies Related to Synthesis and 1, 4-Dipolar Cycloaddition Reactions of Mesoionic Heterocycles.
|Authors:||Yvette Abd El-Sayed Issac|
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The reaction of 2-(substituted amino) pyridine with reactive malonic acid derivatives provided an extremely facile synthesis of the mesoionic compound 4-oxo-4H-pyrido [1, 2-a] pyrimidin-1-ium-2-olates. N, N′-Disubstituted amidine reacted with diethyl malonate to afford 4-quinolone in a one-pot cyclization and rearrangement (type A/I) of 4- oxopyridiniumolate 6. The latter compound was isolated via a reaction of acyclic amidine with AME's. A cycloaddition reaction of the mesoionic pyrimidine 6 with maleic anhydride ...