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Dr. Heba Mohamed KhalilEl-khaiat :: Publications:

Assessment of the Immune Status and DNA Damage in Goats with Experimentally- Induced Hypocuprosis
Authors: Heba M. El-khaiat, Mohamed M. Ghanem, Hala A. Abou-Zeina, Yassein M. Abd El-Raof, Hossam M. El-Attar, Sekena H. Abd El-Aziem
Year: 2016
Keywords: Ceruloplasmin, DNA Damage, Hypocuperosis, Goats, Immunity - Lymphocyte Blastogenesis, Molybdenum, Sulpher, Superoxide Dismutase
Journal: Research in Zoology
Volume: 3
Issue: 1
Pages: 23-30
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Heba Mohamed KhalilEl-khaiat_Assessment of the Immune Status and DNA Damage in.pdf
Supplementary materials Not Available

This study was carried out on 16 adult castrated male Baladi goats with age ranged from 1-1.5 years old and weight range of 19±0.82 kg to investigate the biological role of copper deficiency on the modification of immune status and induction of DNA damage. They were randomized into two groups. The first group (six goats) were apparently healthy and kept as control group, whereas the second group (ten goats) were subjected to experimental induction of secondary copper deficiency by dietary addition of Molybdenum ( MO; 10- 40 mg/kg DM) and Sulpher (S; 1.5-3 g / Kg dry matter) daily for 24 weeks. Blood samples were collected without anti-coagulant every six weeks for determination of serum copper and ceruloplasmin activity. Heparinized blood samples were used for assessment of immune status, DNA damage and erythrocyte superoxide dismutase (SOD). Results showed significant decrease (P

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