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Prof. Mohamed El Sayed Sobhey Abosalem :: Publications:

Title:
HEPATOTOXIC EFFECT OF COPPER SULPHATE AND COBALT CHLORIDE AS FEED ADDITIVES IN ALBINO RATS.
Authors: Saida AMohamed, HH Bakry, ME Abou Salem, Nabila AM, Elham AE
Year: 2014
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: Local
Paper Link: Not Available
Full paper Mohamed El- Sayed Sobhey Abou Salem_COPPER SULPHATE AND COBALT HEPATOTOXIC ITY.pdf
Abstract:

This study is designed to investigate the hepatotoxic effect of copper sulphate and cobalt chloride, which are used as feed additives. One hundred rats classified to five groups. First group used as control; second and third groups were given 1/10 and 1/5 LD50 of CuSo4 respectively, fourth and fifth groups were given 1/10 and 1/5 LD50 of CoCl2 respectively (orally via stomach tube). Body weight was measured weekly. Serum samples used for detection of liver functions. Liver tissue was homogenized for detection of oxidative stress (Reduced glutathione (GSH), Glutathione-s-transferase (GST) and maloneldehyde MDA)). Histopathological examination was performed in liver tissue. Results showed increase level of serum Alanine aminotransferase (ALT), Aspartat aminotransferase (AST), alkaline phosphatase (AP), gamma glutamyl transferase (GGT) and MDA. Decrease level of GSH and GST was detected. It can be concluded that ingestion of copper and cobalt in high doses has hepatotoxic effect on albino rats. Key words: cobalt hepatotoxicity- copper hepatotoxicity- liver enzymes- oxidative stress- heavy metals.

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