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Dr. Mohamed Ahmed Ibraheem Alrabiey :: Publications:

Title:
A comparison of the postoperative analgesic effects of intravenous dexmedetomidine with a combination of dexmedetomidine and bupivacaine infiltration for lower segment caesarean section- a prospective, randomized, controlled study
Authors: Ahmed M. Abd El-Hamid, Mohamed A . Alrabiey , Mohamed H. Abdel Fattah
Year: 2016
Keywords: Postoperative analgesia, dexmedetomidine, wound infiltration, elective caesarean section.
Journal: Ain-Shams Journal of Anesthesiology
Volume: 9
Issue: 2
Pages: 235-239
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Not Available
Supplementary materials Not Available
Abstract:

Background and Aims: This study was designed to compare the postoperative analgesic effect of dexmedetomidine administered intravenously or in wound infiltration with bupivacaine in patients undergoing caesarean section. Methods: Ninety female patients scheduled for caesarean section randomly allocated into three equal groups: group 1 received 100 ml normal saline infusion over 10 minutes. before closure plus wound infiltration with 25 ml of 0.25% bupivacaine at the end of surgery, group 2 received dexmedetomidine 1 μg/kg in 100 ml normal saline infusion over 10 minutes before closure plus wound infiltration with 25 ml of 0.25% bupivacaine at the end of surgery and group 3 received 100 ml normal saline infusion over 10 minutes. before closure plus wound infiltration with dexmedetomidine 1 μg/kg added to 25 ml of 0.25% bupivacaine at the end of surgery. Statistical analysis was done by using ANOVA test for quantitative data and Chi- square or Fisher exact tests for qualitative data. Results: Postoperative morphine consumption was significantly less in patients receiving dexmedetomidine by either route when compared with the control group. Visual analogue scale (VAS) was lower at rest for 6 hours and on cough for 4 hours post-operative in groups 2 and 3 when compared with group 1. Patients in group 2 had more hypotension and sedation compared with other groups. Conclusions: Dexmedetomidine provided effective postoperative analgesia and reduced morphine consumption when administered IV or in wound infiltration with bupivacaine. The incidence of complications was reduced with wound infiltration.

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