You are in:Home/Publications/The Effect of the Substitution Level of Some Dextran-methotrexate Conjugates on their Antitumor Activity in Experimental Cancer Models

Dr. Mohamed Salah Omar :: Publications:

Title:
The Effect of the Substitution Level of Some Dextran-methotrexate Conjugates on their Antitumor Activity in Experimental Cancer Models
Authors: DMITRY NEVOZHAY, RENATA BUDZYNSKA, MONIKA JAGIELLO, URSZULA KANSKA, MOHAMED SALAH OMAR, ADAM OPOLSKI, JOANNA WIETRZYK and JANUSZ BORATYNSKI
Year: 2006
Keywords: Dextran, methotrexate conjugates, antitumor activity, leukemia.
Journal: ANTICANCER RESEARCH
Volume: 26
Issue: Not Available
Pages: 2179-2186
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Mohamed Salah Omar _Sub Lev. Dextran.pdf
Supplementary materials Not Available
Abstract:

Methotrexate (MTX) is widely used in the treatment of a number of oncological and hematological diseases. Due to its known limitations, MTX is often conjugated with different carriers to obtain amended forms of the drug. In this study, the potential influence of the substitution level (loading ratio) of the dextran T10- and T40-based MTX conjugates (D-MTX) on their properties were investigated in vitro and in vivo. The clear dependence of the in vitro antiproliferative effect on the substitution level was established only in the case of the dextran T10-based preparations (T10-MTX conjugates). Conjugates with the higher substitution level had the lower antiproliferative effect. For the dextran T40-based (T40-MTX conjugates) set no similar relationship was observed in the tested range of substitution levels, nor was any dependence observed between the biological properties of the D-MTX preparations in vivo and their substitution levels. However, the difference between the two conjugates was well pronounced in a multipledose schedule, when the advantage of T40-MTX over T10-MTX was cumulative during the prolonged course of administration.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus