This prospective selective study aimed to evaluate the outcome ojmassive blunt trauma patients with uncontrollable bleeding after administration oj recombinant activatedJactor VII (rFVIla). All selected patients admitted to leU once arrived to the hospital and underwent clinical evaluation using the Abbreviated Iryury Scale (AIS) to calculate the Iryury Severinj Score (ISS). Patients were assessed hemodynamically, body temperature and arterial pH were determined. Data concerning haemostatic surgical procedures and transJused amounts packed red blood cells (PC),
Jresh Jrozen plasma (FFP) or platelet (Pit) were recorded. Patients with massive uncontrolled bleeding were inJused with rFVII in a dose oj 90 /1g / kg and the response was observedJor 15-30 minutes if necessary an additional dose oj30 /1g/kg was inJused and in extreme cases a third dose oj 30 /1g/kg was given. The need and amount oj transJusion oj blood products and the need and Jeasibility oj second-look surgery and 48-hrs and I5-days mortality rates were determined. Throughout the study period, 11 trauma patients required rFVII injusionJor massive uncontrollable bleeding. At time oj admission; 7 patients required emergent endotracheal intubation, one required emergency tracheostomy; mean systolic blood pressure was 82 ± 6.4 mmHg and all were acidotic. Two patients had ISS score oj~50, 8 patients had ISS score oj 25- |
