Background: Hemorrhagic transformation (HT) is associated with increased stroke morbidity and mortality. It is the major complication of tissue plasminogen activator (tPA), the only FDA-approved therapy for acute ischemic stroke. , many factors have been related to HT such as severity of stroke, cardiac source of embolism, elevated blood pressure, age, the presence of early ischemic changes in the baseline brain computed tomography (CT) scan, high National institute of health stroke scale (NIHSS) score, and high serum glucose levels have been shown to be associated with a higher risk of hemorrhagic transformation.
Aim of the study: to determine the risk factors for development of hemorrhagic transformation in patients with acute ischemic stroke.
Methods and Results: In this cross sectional study, two hundred patients of acute CVIS (130males & 70 females) were recruited for this study. Assessment of severity of stroke was done based on Canadian Neurological Scale. Assessment of outcome on discharge was done based on Barthel index score. In this study patients who developed hemorrhagic transformation with severe stroke and large infarction were severly dependent with mean age was 68,52±8,05 with highly significant p value < ,001.
Presence of atrial fibrillation was shown to be apredictor of hemorrhagic transformation.
Conclusion: Hemorragic transformation may develop as apart of natural evolution of acute ischemic stroke, or may develop with certain predictors or as complication of treatment.