You are in:Home/Publications/Intervention Program for Improving Insulin Sensitivity and Ameliorating Adipokines altered Serum Levels in Obese and Type-2 Diabetic Children

Dr. Omnia Alsaid Abdallah :: Publications:

Intervention Program for Improving Insulin Sensitivity and Ameliorating Adipokines altered Serum Levels in Obese and Type-2 Diabetic Children
Authors: Adel F. Al-Kholy MD, Omminea A. Abdullah MD, Manal M. Hassaan, Ashraf M.Shaheen MD, Yehia H. Abdel Maqsoud MD, Shereen M. Wahab MD, Eman M. Shaheen MD Maha MD, Emtethal A. Said MD,
Year: 2016
Keywords: Not Available
Journal: Not Available
Volume: Not Available
Issue: Not Available
Pages: Not Available
Publisher: Not Available
Local/International: International
Paper Link: Not Available
Full paper Omnia Alsaid Abdallah_Manuscript (2 files merged).pdf
Supplementary materials Not Available

Objectives: To evaluate therapeutic yield of lifestyle intervention program on body mass index (BMI), insulin resistance (IR) and estimated laboratory markers in obese and diabetic children. Patients & Methods: Thirty-five obese non-diabetic, 35 type-II diabetic and 20 control children and adolescents were studied. All study children underwent 12-weeks intervention consisted of dieting regimen, aerobic exercise with curcumin as herbal therapy. All patients gave blood samples for ELISA estimation of serum insulin, progranulin (PGRN), tumor necrosis factor-α (TNF-α), adiponectin and YKL-40 levels. Insulin resistance was measured by homeostasis model assessment (HOMAIR). Body weight (BW), BMI and HOMA-IR score and laboratory parameters were determined at start and end of the intervention. Results: At end of intervention, BW and BMI, and HOMA-IR variables and score were significantly decreased compared to baseline measures. Patients had significantly higher baseline serum levels of PGRN, YKL-40 and TNF-α, but significantly lower serum adiponectin levels than controls and in diabetics compared to obese children. At end of intervention, serum PGRN and YKL-40 levels were significantly decreased compared baseline levels, despite being still significantly higher than control levels. Serum PGRN and YKL-40 levels were still significantly higher in diabetics than obese patients. Serum levels of TNF-α were still significantly higher in patients than in controls and in diabetics than in obese patients. In comparison to baseline levels, serum levels of TNF-α were significantly lower in obese but non-significantly lower in diabetics. Serum adiponectin levels were significantly lower in diabetics and non-significantly lower in obese compared to control levels, but were significantly higher in obese and non-significantly higher in diabetics compared to their baseline levels with significantly higher levels in obese compared to diabetics. Conclusion: The proposed intervention program allowed reduction of BW and IR and could ameliorate disturbance of adipokines serum levels in obese and diabetic children.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus