Objectives: To evaluate therapeutic yield of lifestyle intervention program on body
mass index (BMI), insulin resistance (IR) and estimated laboratory markers in obese
and diabetic children.
Patients & Methods: Thirty-five obese non-diabetic, 35 type-II diabetic and 20 control
children and adolescents were studied. All study children underwent 12-weeks
intervention consisted of dieting regimen, aerobic exercise with curcumin as herbal
therapy. All patients gave blood samples for ELISA estimation of serum insulin,
progranulin (PGRN), tumor necrosis factor-α (TNF-α), adiponectin and YKL-40
levels. Insulin resistance was measured by homeostasis model assessment (HOMAIR).
Body weight (BW), BMI and HOMA-IR score and laboratory parameters were
determined at start and end of the intervention.
Results: At end of intervention, BW and BMI, and HOMA-IR variables and score
were significantly decreased compared to baseline measures. Patients had
significantly higher baseline serum levels of PGRN, YKL-40 and TNF-α, but
significantly lower serum adiponectin levels than controls and in diabetics compared to obese children. At end of intervention, serum PGRN and YKL-40 levels were
significantly decreased compared baseline levels, despite being still significantly
higher than control levels. Serum PGRN and YKL-40 levels were still significantly
higher in diabetics than obese patients. Serum levels of TNF-α were still significantly
higher in patients than in controls and in diabetics than in obese patients. In
comparison to baseline levels, serum levels of TNF-α were significantly lower in
obese but non-significantly lower in diabetics. Serum adiponectin levels were
significantly lower in diabetics and non-significantly lower in obese compared to
control levels, but were significantly higher in obese and non-significantly higher in
diabetics compared to their baseline levels with significantly higher levels in obese
compared to diabetics.
Conclusion: The proposed intervention program allowed reduction of BW and IR and
could ameliorate disturbance of adipokines serum levels in obese and diabetic