Microvessel Quantitation In Primary Urinary Bladder Carcinom
Hala A. Agina, Ph.D., Ragaey R. Fahmy MD, and Mona H.
Departments of pathology, and community, environmental and occupational medicine. Benha faculty of medicine
a b s t r a c t
To investigate the correlation between microvessel density as a parameter of tumour angiogenesis and other variables in primary urinary bladder carcinoma. We studied 30 cases: 19 cases with squamous cell carcinoma (SCC), 6 cases with transitional cell carcinoma (TCC), and 5 cases of normal urinary bladder epithelium as a control.
P27 expression in non-metastasizing PTC was lower than normal thyroid tissue (P≤ 0.01) and higher than metastasizing PTC (P≤ 0.01), p53 immunoreactivity was present, faint (grade 1) in 2 cases (11%) and moderate (grade 2) in one case ( 5.5%) of non-metastasizing PTC, while 15 (83.5%) cases on non-metastasizing PTCs and all of metastasizing PTCs and normal thyroid tissue had no immunoreactivity for p53. There was no statistically significanct difference among all groups of immunoreactivity for p53. Expression of Bax in patients with PTC was more than normal thyroid tissue ( P≤ 0.01). However, non-metastasizing and metastasizing PTC was similar. The results indicate that the metastasizing PTC showed significantly low CD44 expression than the non-metastasizing PTC (p ≤ 0.05), also the metastasizing and non-metastasizing PTC showed significantly less CD44 expression than the normal tissue (p≤ 0.05).
A significantly higher MVD was observed in squamous cell carcinoma compared with that of transitional cell carcinoma (p= < o.o5). there is as well as a significant positive correlation between grade, stage, MVD and the presence of vascular invasion
Research in Benha M.J. 14 (2)(1997) 491–501.