The Asparagus racemosus was evaluated for its hepatoprotective activities against paracetamol inducedhepatotoxicity in rats. Forty rats were used divided into 2 groups, normal control: Composed from 10rats and Hepatotoxicity induced group composed from 30 rats administrated of paracetamol by dose1gm/kg b. wt. orally. For 10 days, then every 72h. Until the end of experiment time. This groupsubdivided into 3 subgroup: 1-Paracetamol group: 10 rats as control negative. 2-Silymarin treated group:10 rats taken silymarin by dose 100 mg/kg daily P.O. for (15) days (Kumar et al., 2011). 3-Asparagustreated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O.for 15 days. (Kumar et al., 2011and Sara et al., 2013). Paracetamol-induced a significant increase in,aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), withmarked reduction in superoxide dismutase (SOD) and catalase (CAT) activities. Treatment of rats withAsparagus racemosus (500 mg/kg b. wt.) significantly altered serum marker enzymes and antioxidantstatus to near a normal level against paracetamol-treated rats. Such hepatoprotective activities ofAsparagus racemosus were comparable to silymarin administrated (100 mg/kg b. wt. p.o.). The resultsindicate that the hepatoprotective properties of Asparagus racemosus against paracetamol-inducedhepatotoxicity in rats |
