Background: Postpartum hemorrhage (PPH) is excessive blood loss after childbirth, and has been defined as blood loss >500 ml in normal vaginal delivery, or >1000 ml after cesarean section (CS). Postpartum hemorrhage PPH accounts for nearly one quarter of all maternal deaths worldwide.
Purpose: To compare the efficacy and safety of carbetocin with those of oxytocin in reducing intra-operative and postoperative blood loss at caesarean section.
Patients and Methods: This study is a prospective randomized (closed envelop) comparative study conducted in the Obstetrics and Gynecology Department of Benha university hospital and Matria Teaching Hospital. During the period from December 2016 till December 2017. The study included 200 pregnant women undergoing elective cesarean section at term (completed 37 weeks of gestation) with singleton pregnancy divided into 2 groups, group 1 was administered 10 IU oxytocin and group 2 was administered 100μgcarbetocin.
Results: Carbetocin was associated with a significantly reduced need for additional uterotonic agents (8% versus21%, P value=˂0.009) compared with oxytocin in women following C.S. there is significant difference in the amount of estimated blood loss (p value=0.0001) and the incidence of postpartum hemorrhage(p value =0.179), adverse effects, our study show non significant difference between two group.
Conclusion: Carbetocin appears to be more effective than oxytocin for prevention of postpartum hemorrhage in patient undergoing elective cesarean section. According to the results of this study it is found that there is a good overall agreement that Carbetocin might be effective in controlling the amount of blood loss during cesarean section and giving a better chance in prevention of atonic post partum Hemorrhage. |
