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Course Title[Course Code]:Biotechnology (Advanced)[Gen 706]

Faculty: Agriculture
Department: Genetics
Program: Molecular and Biochemical Genetics
Compulsory / Elective:Compulsory
Postgraduate(Doctoral-First Semester or Second Semester)
Hours:
Lecture:( 2 ) Practical / Clinical:( 2 ) Tutorial:( - )

Course Description:
Chromosome structure, organization: Chromatin structure, nucleosomal and higher order structures, morphology and basic functions; Techniques in the study of chromosomes and applications. Mitotic and meiotic chromosomes, banding, karyotyping, chromosome labeling and cell cycle analysis, in situ hybridization, chromosome painting, gene mapping, somatic cell hybrids, premature chromosome condensation; Special types of chromosome-sex chromosomes, sex chromatin, B-chromosome, polytene and lambrush chromosomes; Numerical and structural changes in the chromosome. Mechanisms of sex determination in plants and animals. Dosage compensation; Genome organization in viruses, prokaryotes and eukaryotes (animals and plants); Organization of nuclear and organellar genomes; c-value paradox; Techniques in genome analysis, genome mapping and functional genomics; Repetitive DNA-satellite DNAs and interspersed repeated DNAs, Transposable Elements, LINES, SINES, Alu family, mechanisms of DNA amplification, genome evolution; Fine structure of gene, split genes, pseudogenes, overlapping genes and multigene families. DNA and RNA as genetic material; Chemistry and structure of DNA.