T?ie effect of nasal obstruction on the nasal and middle ear mucosa
was studied on 138 albino rats with unilateral and bilateral nasal ob
struction for variable periods up to 3 months.
Group 1 was composed of100 rats which were subjected to unilateral
nasal closure. They were divided into 5 equal subgroups and
were sacrificed after variable periods so as to study the histological
changes of the nasal and ear mucosa
Group II was composed of 38 rats, these being subjected to bilateral
nasal closure. These had died within 9 days.
The nasal mucosa of the open side showed squamous metapla
sia vascular congestion and ciliary destruction while in the closed
side there was increased secretory activity without epithelial dam
age.
The ear mucosa showed no changes in the side of open nostril while
mucosal oedema occured in the side of closed nostril after 2 weeks.
The chages seen in the nasal mucosa of the closed side of the nose ex
plain the beniftdal effect of nostril closure in atrophtc rhinitis. |
