Oxidant stress has a role in pathophysiology of many diseases. However
its role in myocardial infarction is not fully clear. Also,prostaglandins
have a relation to many diseases however, its relation to myocardial infarction
is not fully investigated. Also, it is not known well whether prostag
landins mediate the card ioprotective effect of anti-oxidant vitamins E
and C. The aim of the present work was to investigate the role of oxidant
stress and prostaglandin in the pathgenseis of myocardial infarction and
possible relation between them /The results of the present study showed
that injection of vitamin E and vitamin C ( Known anti-oxidant vitamins)
reduced the myocardial infarction induced by isoprenalin injection .thus
denoting that the myocardial infarction is largely due to oxidant stress.
Also the results showed that injection of voltaren ( a prostaglandin synthesis
inhibitor) caused an increase in myocardial infarction induced by
isoprenalin signyking a prostaglandin cardioprotective action. The results
showed also that injection of voltaren together with vitamin E nearly abolished
the cardioprotective action of vitamin E. This,proved that the cardioprorective
effect of vitamin is mediated at least partially through prostaglandin.
In contrast ,injection of voltaren with vitamin C did not affect the
cardiprotective action of vitamin C.This means that the card iprotective action
of vitamin C is not mediated through prostaglandin. |
