Oxygen derived free radicals were found to be one of the major mechanisms
which lead to gastric ulceration . In this work the role of vitamins E
& C as antioxidant agents in protection against and healing of gastric ulcers
was investigated. 48 albino rats were included in this study .They
were divided into a control group (6 rats) ,induction group (6 rats) ,Vit C
group (18 rats) and Vit E groups (18 rats) . The control rats were injected
intraperitoneally (ix)) with normal saline for 14 days in the induction
group the rats were injected with hydrocortisone sodium succinate (i.p)
for 14 days for induction of gastric ulceration .Vit C group were divided
into 3 subgroups each one of them includes 6 rats .The Vit C subgroups
were injected with Vit C Lift in a dose of 2 mg/ kgm /day for 14 days before,
during and after corticosteroid injection .Vit E group were also subdivided
into 3 subgroups 6 rats each , which were injected with vit E in a
dose of 30 mg / 100 gm daily S.0 for 14 days before ,during and after corticosteroid
injection. The results showed that corticosteroid injection for
14 days resulted in gastric ulcer formation in all the injected rats. Treatment
of rats with vitamin C and E significantly reduced the ulcer formation
and help the healing of the already formed ulcers. The best
protective effect was obtained when rats were supplemented with vitamin
C and E during the peroid of corticosteroid injection. There were no
marked differences between both vitamins in protection or healing of gastric
ulcer.
We conclude that vitamin C and vitamin E have a signficant protective
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Nasr A. Belacy et al....
and healing effect against corticosteroid induced gastric ulceration in rats
,most probably due to their antioxidant effects. |
