This research was conducted on 15 cases, 10 casescomplaining of recurrent
aphthus stomatitis minor type (m R A S) and 5 control volunteers.
Biopsy is taken from the minor salivary glands of lower lip front patients
during the ulcerative phase as well as during ulcer free period after
complete healing of the ulcers, and biopsy is taken also from volunteers
after fulfilling the data that they have no RAS at any time of thier life, biopsy
is taken under local anaesthesia, the biopsy specimens are subjected
to examination under light microscopy after staining with toludine
blue, subjected also for histochemical reactions for succinate dehydrogenase
enzyme. Acid phosphatase enzyme and alkaline phosphatase lasty
the biopsy specimens were subjected for election microscopic study. The
results showed that during severe attack the secretion of mucus acini
was less in mount but concentrated so that its chemical nature becomes
mainly of acidic mucopolysaccharides which give the secretion an acid
nature weakening the covering epithelium and cause the ulcerative condition.
Morever this ulcerative eruptions were enhaced by proteolytic enzymes
secreted from the excretory duct cells where the fritters secrete serous
fluid rich in these proteolytic enzymes.so we conclude that RAS can
be considered one of the diseases which is induced by hyperacidity. It's
treatment has to be modffied to include antiulcer therapy especially for
prevention of recurrences, more studies has to be done to varify these
findings and to prove if only the secretion in the buccal mucosa playing
role in hyperacidity. |
