| Title: | BONE MINERAL DENSITY IN
PREMENOPAUSAL WOMEN WITH
SYSTEMIC LUPUS ERYTHEMATOSUS
'INFLUENCE OF SERUM LEPTIN, DISEASE
| •RELATED VARIABLES AND USE OF
CORTICOSTEROIDS* |
| Full paper | Not Available |
| Abstract: |
Objective: To evaluate bone mineral density (BMD) in premenopausal female patients with SLE and to assess the influence of serum leptin, disease related variables and use of corticosteroids. We analysed only the premenopausal SLE patients to eliminate the confounding effect of menopause on bone loss. sMethods : Forty pre-menopausal patients with systemic ;lupus erythematosus (SLE) who fulfilled the revised criteria for classification of SLE of the American College of Rheumatology *and twenty healthy control subjects apparently free from any relevant disease were included in this study. All patients were subjected to full history taking, thorough clinical examination and assessment of disease activity using the SLE disease activity index (SLEDAI), assessment of functional status using Steinbrocker grades as well as measurement of serum leptin level with ELLSA. Bone densitometry was performed by Dual Energy X-Ray Absorptiometry (DEXA) at the lumbar spine from L2-4 and left hip (femoral neck, trochanter). Results: Our results showed a high frequency of low BMD at the lumbar spine (L2-IA) and left hip (femoral neck, trochanter) as diagnosed by using DEXA in premenopausal |