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ABSTRACT:
Objective: To assess plasma and synovial fluid levels of soluble CD14 (sCD14) in
Rheumatoid arthritis (RA) and its association *to ESR, CRP, interleukin-6 (IL-6) and
disease activity in an attempt to throw light on its possible role as an acute phase
protein.
Methods: This study included 35 patients with RA , 25 patients with osteoarthritis
(OA) and ten apparently healthy subjects (as control groups). Serum and synovial fluid
sCD14 and serum interleukin-6 (IL-6) were determined by ELISA. CRP and ESR were
measured.
Results: A highly significant difference in levels of sCD14 in serum and synovial
fluid in RA patients as compared to OA or control groups. Serum IL-6 and CRP levels
were higher in RA patients than in OA or control groups while there was non significant
difference between serum and synovial fluid SCD14 levels in RA patients .There were
highly significant positive correlations between sCD14 levels in serum and synovial
fluid in rheumatoid arthritis patients as compared to disease duration, ESR, CRP, IL-6 or
disease activity.
Conclusion: The elevation of serum and synovial fluid levels of sCD14 appears to be
a common feature in RA patients. It shows high significant positive correlations as
compared to disease duration, ESR, CRP, a classical acute phase protein (APP), IL-6, a
-cytokine. known to regulate the synthesis of APP in the liver or disease activity. So
sCD14 can beeonsiderd as an acute phase protein.
STUDY OF SERUM AND SYNOVIAL FLUID LEVELS OF
SOLUBLE CD14 IN PATIENTS WITH RHEUMATOID ARTHRITIS:
ITS ROLE AS AN ACUTE PHASE PROTIEN |
