Oxidant stress has a role in pathophysiology of many diseases. However
its role in myocardial infarction is not fully clear. Also,prostaglandins
have a relation to many diseases however, its relation to myocardial infarction
is not fully investigated. Also, it is ru:)t known well whether prostaglandins
mediate the cardioprotective effect of anti-oxidant vitamins E
and C. The aim of the present work was to investigate the role of oxidant
stress and prostaglandia in the pathgenseis of myocardial infarction and
possible relation between them .The results of the present study showed
that injection of vitamin E and vitamin C ( Known anti-oxidant vitamins)
reduced the myocardial infarction induced by isoprenalin injection ,thus
denoting that the myocardial infarction is largely due to oxidant stress.
Also the results showed that injection of voltaren ( a prostaglandin synthesis
inhibitor) caused an increase in myocardial infarction induced by
isoprenalin signifying a prostaglandin cardioprotective action. The results
showed also that injection of voltaren together with vitamin E nearly abolished
the cardioprotective action of vitamin E. This ,proved that the cardioprotective
effect of vitamin is mediated at least partially through prostaglandin
. In contrast ,injection of voltaren with vitamin C did not affect the
cardiprotective action of vitamin C.T'his means that the card iprotective action
of vitamin C is not mediated through prostaglandin. |
