Recent years have seen an increasing interest in the study of the
aging male, with particular interest in that mole hormone replacement -
can improve quality of life (Verrnulen. 2001) .
This study was designed to investigate the effects of testosterone replacement
on SH,and PR!.. exercise responses in castrated male rats. Fifty
six adult male albino rats were included in this study. The rats were
classified into seven groups: Group I Sham castrated. Group II Exercised
sham castrated . Group III Castrated. Group IV ExerciSed castrated .
Group V Exercised castrated testosterone replacement (10 mg/ kg/ week)
. Group VI Exercised castrated testosterone replacement double dose .
Group VII Exercised castrated testosterone replacement half dose. After
one month of . experiments all rats were sacrificed Blood samples were
collected and GH and PRL levels were estimated in all animal sera.
Our results showed that exercise increase both GH and PRL. in sham
castrated rats. This response is abolished in castrated rats. Testosterone
replacement increase both GH and PRI, response to exercise and this efl
fect is dose dependent: GPI and PRL release response increase by double
dose while they decrease by half dose replacement
We conclude a beneficial effect of testosterone replacement in old aged
men with moderate training that improve bone mass and prevents the unfavorable
changes in organs upon which androgen acts through increase
GH and PRL response to exercise. |
