The erythrocyte glutathione peroxidase (GP) level and the concentration
of serum selenium were assessed in 20 patients with active systemic
lupus erythematosus and their correlation with the disease activity were
studied. 12 heathy persons, matched for age and sex were taken as a
control group. AU cases were subjected to clinical assessment and laboratory
investigations. There was a significant decrease of erythrocyte peroxidase
level and serum selenium level in patients with systemic lupus
erythematosus as compared to the controls. Erythrocyte glutathione peroxid
nse and serum selenium, showed a negative significant correlation
with systemic lupus erythematosus activity index score (SLEDAI). From
the previous results we concluded that, the decreased GP activity leads
to the lack of antioxidative capacity of the glutathione peroxidase/ reductase
system and this could have a pathogenic role in the pathogenesis of
systemic lupus erythematosus and antioxidants can be used as markers
to predict prognosis in patients with systemic lupus erythematosus. |
