This study was performed to assess Q-T dispersion in patients with
acute myocardial infarction (AMI) treated with thrombolytic therapy ver
sus conventional therapy. The study population included 50 patients: 25
were treated with streptoldnase (SK) and the other 25 did not received
such therapy due to contraindication. Their ages ranged between 37 to
80 years (mean 58.4 + 10.46). Thirty-six ofthem (72%) had anterior and
14 (28%) haa inferior infarction. Twenty-five, age and sex-matched
healthy subjects served as control group. Q-T dispersion and dispersion
ratio were estimated thrice in SK-treated group (on admission, 2hrspost-
Sk and predischarge), twice in non-SK treated group (on admission and
predischarge) and once for controls. Statistical analysis of the results
showed thatpatients on admission had highl^ significant increase in Q-T
dispersion parameters compared to controls (p < 0.001). Subgroup analy
sis showed highly signficant increase in Q-T dispersion parameters in
patients who were complicated compared to those who were not compli
cated with complex ventricular arrhythmias during hospital course (p
<0.01). Also there was highly signficant increase in these parameters in
diabetic compared to nondiabetic patients (p < 0.01). Patients who were
treatedwith SK showed highly significant decrease in dispersionparame
ters 2 hours after SK infusion and on dischargeform hospital compared
to that on admission (p < 0.01) |
